Grape Seed Extract 140mg 30 Capsules

Oxiprovin is a health supplement that contains grape seed extract which is a source of antioxidants (oligomeric proanthocyanidins) for the maintenance and preservation of good health and venous health.

Did you know:

• Antioxidants neutralise harmful free radicals thereby reducing oxidative stress and supporting metabolic health.
• Antioxidants may assist individuals who follow a sedentary lifestyle, have a poor diet and high stress levels.

How to take

Adults over 18 years:

For the maintenance of good health: Take 1 capsule daily.

For times of increased demand or for venous health: Take 2-3 capsules daily.

Take with water. For oral use only.

For venous health: Use for a minimum of 1 month for beneficial effects.

Ingredients

Each capsule contains: Vitis vinifera (L.) (Grape seed extract) 140 mg (Source of oligomeric proanthocyanidins)

Sugar free.

Excipients: Capsule content: Magnesium stearate (E470b), Microcrystalline cellulose (E460). Hard gelatine capsule: Bovine gelatine (E441), Titanium dioxide (E171).

This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use.

Warnings

Contraindications:

• Hypersensitivity to the active substance, Vitis vinifera (L.) (grape and/or grape seed extract), or to any of the excipients.
• Anticoagulant or antiplatelet medicine.
• OXIPROVIN® may be contraindicated if taken prior to surgery, as there may be an increased risk of bleeding.
• Patients younger than 18 years.

Special warnings and precautions for use: Patients should be informed to consult their doctor, pharmacist, or health care provider:

• If they are pregnant or breastfeeding.
• In venous conditions, if there is inflammation of the skin, thrombophlebitis or subcutaneous induration, severe pain, ulcers, sudden swelling of one or both legs, cardiac and/or renal insufficiency.
• For venous health use of OXIPROVIN® beyond 3 months or if symptoms worsen.

Perioperative: Grape seed extracts may increase the risk of excessive bleeding and bruising if used prior to surgery. In vitro evidence suggests that grape extracts can decrease platelet aggregation. Discontinue at least 2 weeks prior to elective surgical procedures.

Pregnancy: The safety of OXIPROVIN® during pregnancy has not been established. Consult a relevant health care provider prior to use if you are pregnant.

Breastfeeding: The safety of OXIPROVIN® during lactation has not been established. Consult a relevant health care provider prior to use if you are breastfeeding.

Interactions: The following interactions with other medicines may be possible:

• Grape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant/antiplatelet medicine.
• OXIPROVIN® could influence the levels of the following liver enzymes: Cytochrome P450 2D6 (CYP2D6), Cytochrome P450 2E1 (CYP2E1), Cytochrome P450 3A4 (CYP3A4), and Cytochrome P450 2C9 (CYP2C9). Although no interactions have been reported, the use of OXIPROVIN® together with medicines that are also metabolised with the same pathway should be discussed with and monitored by a doctor or relevant health care provider.
• OXIPROVIN® when used over a long period may decrease the effects of midazolam.

Effects on ability to drive and use machines: It is not always possible to predict to what extent OXIPROVIN® may affect mental and/or physical ability to perform or execute tasks or activities requiring mental alertness, judgment and/or sound coordination and vision. Patients should ensure that they do not engage in the above activities until they are aware of the measure to which OXIPROVIN® affects them.

Side effects: Orally, grape seed extract is generally well tolerated.

• Hypersensitivity or allergic reactions (e.g., itching, rash, urticaria) (frequency unknown).
• Headache (less frequent).
• Sore throat, cough, allergic rhinitis, nasopharyngitis (less frequent).
• Abdominal pain, nausea, diarrhoea (less frequent).
• Joint pain, lumbago (less frequent).

Above reactions have been reported with use of grape seed extract, but these effects occur at rates similar to placebo. Adverse effects are more likely to occur at doses above the tolerable upper intake.

Overdose: In overdose, side effects can be precipitated and/or be of increased severity. Treatment of overdose should be symptomatic and supportive.

Storage: Store at or below 25 °C in a cool, dry place. Store in the original package.