{"product_id":"salvita-propolis-tincture-30ml","title":"SALVITA - Propolis Tincture - 30ml","description":"\u003cp\u003ePropolis Tincture – Natural Anti Biotic\u003c\/p\u003e\u003cp\u003ePropolis is ideal for helping the body resist infections, alleviating colds \u0026amp; flu and supporting the upper respiratory tract, plus much more.\u003c\/p\u003e\u003cp\u003eNature’s Antibiotic\u003c\/p\u003e\u003cp\u003e100% propolis extract\u003c\/p\u003e\u003ch3\u003eIngredients\u003c\/h3\u003e\u003cp\u003eSouth African non-irradiated bee propolis, ethanol\u003cbr\u003e Contains no colourants, fillers, gluten, or preservatives\u003c\/p\u003e\u003ch3\u003eHow to take\u003c\/h3\u003e\u003cp\u003eTake daily as a food supplement to maintain natural immunity and treat long-term conditions. It can also be used to treat\u003cbr\u003e acute conditions, infections, and inflammation.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eAcute conditions\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eAdults: 15 drops\u003cbr\u003e Children 3 – 6 years: 2 – 3 drops\u003cbr\u003e Children 6 – 12 years: 7 – 10 drops\u003c\/p\u003e\u003cp\u003eDilute in raw honey or 50 ml of water and take 3 times daily\u003c\/p\u003e\u003cp\u003eMaintenance dose: half the therapeutic dose twice daily\u003c\/p\u003e\u003cp\u003eFor sore throat: gargle and swallow\u003c\/p\u003e\u003cp\u003eUlcers and cold sores: add undiluted drops directly to the infected area\u003c\/p\u003e\u003cp\u003eFor ear infections: mix 3 drops of propolis tincture with 5 ml of olive oil and drop 2x drops into the infected ear three times daily.\u003cbr\u003e Eye infections: Dilute 5 drops of propolis in 25 ml of water and wash the infected eye with this dilution three to four times a day.\u003c\/p\u003e\u003cp\u003eTo eliminate alcohol, add drops to hot water, allow it to cool and drink.\u003c\/p\u003e\u003ch3\u003eActions\u003c\/h3\u003e\u003cul\u003e\n\u003cli\u003ePropolis is ideal for helping the body resist infections, alleviating colds \u0026amp; flu and supporting the upper respiratory tract.\u003c\/li\u003e\n\u003cli\u003ePropolis has hepatoprotective, cardioprotective, antihypertensive, hypoglycemic, and hypolipidemic activities. Propolis exerts this hepatoprotective effect through the inhibition of phase I enzymes and the induction of phase II enzymes\u003c\/li\u003e\n\u003cli\u003ePropolis-derived flavonoids exhibit powerful antioxidant activities and are capable of scavenging free radicals and thus protecting the cell membrane against lipid peroxidation.\u003c\/li\u003e\n\u003cli\u003ePropolis extract has the ability to modulate both pro-inflammatory and anti-inflammatory cytokines. Propolis extracts also suppressed the production of TNF-α and IL-6 cytokines, while increasing the production of the anti-inflammatory IL-10 cytokine.\u003c\/li\u003e\n\u003cli\u003eThe anticancer effects of propolis appear to be mediated in part by cytostatic effects and immunomodulatory effects.\u003c\/li\u003e\n\u003cli\u003eTaken orally offers spectacular results in the resolution of the hemorrhagic process as a consequence of cancer radiation therapy, which favours fast healing of post-radiotherapy ulceration and normalisation of the blood circulation in the periphery of the lesion. The duration of therapy is generally shorter than conventional therapy, while the side effects are generally negligible.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eContents\u003c\/h3\u003e\u003cp\u003eBee propolis 30ml\u003cbr\u003e Ethyl Acohol (70% alc\/ vol)\u003c\/p\u003e\u003ch3\u003eWarnings\u003c\/h3\u003e\u003cp\u003eSeveral scientific studies indicate that propolis does not have toxicity or side effects in animal models or humans1 .\u003c\/p\u003e\u003cp\u003eNot recommended for people allergic to bee products, pregnant women and children under 3 years of age.\u003c\/p\u003e\u003cp\u003eNote that propolis does not replace a balanced diet and a healthy lifestyle.\u003c\/p\u003e\u003ch3\u003eGood For\u003c\/h3\u003e\u003cp\u003eAnti Bacterial, Antiviral, Respiratory Problems\u003c\/p\u003e\u003ch3\u003eResearch and References\u003c\/h3\u003e\u003cp\u003eThe complex chemical composition of propolis depends on the plant origin, geographical location and the collection seasons 2. Propolis contains various phytochemicals in different concentrations, such as phenolics, flavonoids, and alkaloids, which are responsible for its biological and pharmaceutical properties. Asian, African, and European propolis contains predominantly phenolics and flavonoids such as naringenin, galangin, pinocembrin, apigenin, pinobanksin, quercetin, cinnamic acid and its esters, kaempferol, chrysin, cinnamyl caffeate, cinnamylidene acetic acid, caffeic acid, rutin, ferulic acid, gallic acid, p-coumaric acid, aromatic acids and their esters 1,3.\u003c\/p\u003e\u003cp\u003eAnti-inflammatory and immunomodulation\u003c\/p\u003e\u003cp\u003ePropolis extract has the ability to modulate both pro-inflammatory and anti-inflammatory cytokines 3. Therefore, propolis may assist in the treatment and\/or prevention of inflammatory diseases by acting as a natural anti-inflammatory agent by modulating the production of immune mediators 3.\u003c\/p\u003e\u003cp\u003eIn several studies, it has been shown that propolis has immunological activities. For example, Brazilian green propolis\u003cbr\u003e exhibited antioxidant and anti-inflammatory activities in LPS-stimulated macrophage cell line J774A.1 by inhibiting the\u003cbr\u003e production of reactive oxygen species, nitric oxide, and the pro-inflammatory cytokines TNF-α, IL-1, and IL-6 3.\u003c\/p\u003e\u003cp\u003ePropolis also exhibits anti-inflammatory effects through the affecting of Toll-like receptors (TLRs), which recognise various\u003cbr\u003e microbial receptors called pathogen-associated molecular patterns (PAMPs). Consequently, pro-inflammatory cytokines are released through the activation of NF-kB and other transcriptional factors. This response is mediated by B and T cells and results in pathogen-specific adaptive immunity. In an in vivo study, propolis administration to C57BL\/6 mice for 14 days led to reduced production of IL-1, IL-6, IL-2, IL-10 and IFN-c from spleen cells. Furthermore, ethanolic propolis extract reduced the expression of IL-17 in collagen-induced arthritis in mice, indicating its benefits in autoimmunity. Propolis extracts also suppressed TNF-α and IL-6 production in a dose-dependent manner in LPS-stimulated human peripheral blood mononuclear cells. Propolis also increased the production of anti-inflammatory IL-10 in a dose-dependent manner. The cytokine IL-10 is a potent anti-inflammatory mediator; it reduces and terminates the ongoing inflammatory process 3.\u003cbr\u003e Therefore, propolis and its constituents can be considered as potent natural anti-inflammatory agents that act by modulating immune responses.\u003c\/p\u003e\u003cp\u003eAntimicrobial properties\u003c\/p\u003e\u003cp\u003eDetermination of the zone inhibitions of propolis in different bacteria strains showed that Gram-positive strains are more\u003cbr\u003e sensitive than Gram-negative bacteria. Touzani et al. found that in the disc diffusion method, S. faecalis and S. aureus were the most sensitive and P. aeruginosa was the most resistant to propolis 3. Research showed that Bacillus subtilis and Streptococcus pyogenes were highly sensitive Gram-positive microorganisms to ethanol propolis extracts. In contrast, the aqueous extract of propolis showed low bactericidal activity against Gram-negative bacteria 1.\u003cbr\u003e However, it has been reported to have antibacterial activity against both Gram-positive and Gram-negative microorganisms, including multidrug-resistant bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA). Furthermore, it was found that Turkish propolis has anti-tuberculosis activity against different types of mycobacteria 1.\u003cbr\u003e It is documented to have different antibacterial mechanisms, including inhibition of cell division, collapsing cell membranes and cell walls, inhibition of bacterial motility, enzyme inactivation, bacteriolysis, and protein synthesis. These multi-target effects encouraged researchers to employ propolis to overcome the potential in drug resistance in microorganisms by combining propolis with antibiotics. Propolis extracts synergistically enhanced the efficacy of antibiotics, especially those that act on cell wall synthesis, such as vancomycin and oxacillin 1.\u003c\/p\u003e\u003cp\u003eIn addition, many studies have documented the remarkable action of propolis against many types of microorganisms,\u003cbr\u003e including yeast, viruses, bacteria, and parasites. Al-ani et al. demonstrated antifungal activity against reference strains and clinical isolates. Candida glabrata, Candida parapsilosis, and Candida tropicalis were the most sensitive Candida species 1. Antiparasitic activity has been demonstrated against Trichomonas and amoebic infections.\u003c\/p\u003e\u003cp\u003eAnticancer effect\u003c\/p\u003e\u003cp\u003eMany reports have indicated that different types of honey and propolis extracts significantly inhibit cell growth and reduce the differentiation or proliferation of cells from various tumour cell lines. It was found that ethanolic extract of propolis from southern Poland exhibited 25% cytotoxicity in prostate cancer cells. An ethanolic extract of propolis was cytotoxic in a MCF-7 cell line. Compared to these results, water-extracted propolis exhibited relatively low grade of cytotoxic effects 3.\u003c\/p\u003e\u003cp\u003eReferences\u003c\/p\u003e\u003cp\u003e1. Al-Ani I, Zimmermann S, Reichling J, Wink M. Antimicrobial Activities of European Propolis Collected from Various Geographic Origins Alone and in Combination with Antibiotics. Medicines (Basel). Jan 3 2018;5(1)doi:10.3390\/medicines5010002\u003cbr\u003e 2. Zhang T, Omar R, Siheri W, et al. Chromatographic analysis with different detectors in the chemical characterisation\u003cbr\u003e and dereplication of African propolis. Talanta. Mar 2014;120:181-90. doi:10.1016\/j.talanta.2013.11.094\u003cbr\u003e 3. Touzani S, Embaslat W, Imtara H, et al. In Vitro Evaluation of the Potential Use of Propolis as a Multitarget Therapeutic Product: Physicochemical Properties, Chemical Composition, and Immunomodulatory, Antibacterial, and\u003cbr\u003e Anticancer Properties. Biomed Res Int. 2019;2019:4836378. doi:10.1155\/2019\/4836378\u003c\/p\u003e\u003ch3\u003eBefore you use it\u003c\/h3\u003e\u003cp\u003eRead the label on the pack for directions, ingredients and warnings, and follow them. If you're pregnant, breastfeeding, taking medication or managing a condition, ask your healthcare practitioner or one of our consultants first: WhatsApp 076 913 5059.\u003c\/p\u003e","brand":"SALVITA","offers":[{"title":"Default Title","offer_id":67746896183606,"sku":"759649476089","price":291.53,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/9136\/3126\/files\/759649476089-onelife.jpg?v=1792161621","url":"https:\/\/onelife.co.za\/products\/salvita-propolis-tincture-30ml","provider":"One Life Health Store","version":"1.0","type":"link"}