{"product_id":"oxiprovin-grape-seed-extract-140mg-30-capsules","title":"OXIPROVIN - Grape Seed Extract 140mg - 30 Capsules","description":"\u003cp\u003eOxiprovin is a health supplement that contains grape seed extract which is a source of antioxidants (oligomeric proanthocyanidins) for the maintenance and preservation of good health and venous health.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eDid you know:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eAntioxidants neutralise harmful free radicals thereby reducing oxidative stress and supporting metabolic health.\u003c\/li\u003e\n\u003cli\u003eAntioxidants may assist individuals who follow a sedentary lifestyle, have a poor diet and high stress levels.\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch3\u003eHow to take\u003c\/h3\u003e\u003cp\u003e\u003cstrong\u003eAdults over 18 years:\u003c\/strong\u003e\u003c\/p\u003e\u003cp\u003eFor the maintenance of good health: Take 1 capsule daily.\u003c\/p\u003e\u003cp\u003eFor times of increased demand or for venous health: Take 2-3 capsules daily.\u003c\/p\u003e\u003cp\u003eTake with water. For oral use only.\u003c\/p\u003e\u003cp\u003eFor venous health: Use for a minimum of 1 month for beneficial effects.\u003c\/p\u003e\u003ch3\u003eIngredients\u003c\/h3\u003e\u003cp\u003eEach capsule contains: Vitis vinifera (L.) (Grape seed extract) 140 mg (Source of oligomeric proanthocyanidins)\u003c\/p\u003e\u003cp\u003eSugar free.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eExcipients:\u003c\/strong\u003e Capsule content: Magnesium stearate (E470b), Microcrystalline cellulose (E460). Hard gelatine capsule: Bovine gelatine (E441), Titanium dioxide (E171).\u003c\/p\u003e\u003cp\u003eThis unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use.\u003c\/p\u003e\u003ch3\u003eWarnings\u003c\/h3\u003e\u003cp\u003e\u003cstrong\u003eContraindications:\u003c\/strong\u003e\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eHypersensitivity to the active substance, Vitis vinifera (L.) (grape and\/or grape seed extract), or to any of the excipients.\u003c\/li\u003e\n\u003cli\u003eAnticoagulant or antiplatelet medicine.\u003c\/li\u003e\n\u003cli\u003eOXIPROVIN® may be contraindicated if taken prior to surgery, as there may be an increased risk of bleeding.\u003c\/li\u003e\n\u003cli\u003ePatients younger than 18 years.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eSpecial warnings and precautions for use:\u003c\/strong\u003e Patients should be informed to consult their doctor, pharmacist, or health care provider:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eIf they are pregnant or breastfeeding.\u003c\/li\u003e\n\u003cli\u003eIn venous conditions, if there is inflammation of the skin, thrombophlebitis or subcutaneous induration, severe pain, ulcers, sudden swelling of one or both legs, cardiac and\/or renal insufficiency.\u003c\/li\u003e\n\u003cli\u003eFor venous health use of OXIPROVIN® beyond 3 months or if symptoms worsen.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003ePerioperative:\u003c\/strong\u003e Grape seed extracts may increase the risk of excessive bleeding and bruising if used prior to surgery. In vitro evidence suggests that grape extracts can decrease platelet aggregation. Discontinue at least 2 weeks prior to elective surgical procedures.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003ePregnancy:\u003c\/strong\u003e The safety of OXIPROVIN® during pregnancy has not been established. Consult a relevant health care provider prior to use if you are pregnant.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eBreastfeeding:\u003c\/strong\u003e The safety of OXIPROVIN® during lactation has not been established. Consult a relevant health care provider prior to use if you are breastfeeding.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eInteractions:\u003c\/strong\u003e The following interactions with other medicines may be possible:\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eGrape extracts may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant\/antiplatelet medicine.\u003c\/li\u003e\n\u003cli\u003eOXIPROVIN® could influence the levels of the following liver enzymes: Cytochrome P450 2D6 (CYP2D6), Cytochrome P450 2E1 (CYP2E1), Cytochrome P450 3A4 (CYP3A4), and Cytochrome P450 2C9 (CYP2C9). Although no interactions have been reported, the use of OXIPROVIN® together with medicines that are also metabolised with the same pathway should be discussed with and monitored by a doctor or relevant health care provider.\u003c\/li\u003e\n\u003cli\u003eOXIPROVIN® when used over a long period may decrease the effects of midazolam.\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003e\u003cstrong\u003eEffects on ability to drive and use machines:\u003c\/strong\u003e It is not always possible to predict to what extent OXIPROVIN® may affect mental and\/or physical ability to perform or execute tasks or activities requiring mental alertness, judgment and\/or sound coordination and vision. Patients should ensure that they do not engage in the above activities until they are aware of the measure to which OXIPROVIN® affects them.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eSide effects:\u003c\/strong\u003e Orally, grape seed extract is generally well tolerated.\u003c\/p\u003e\u003cul\u003e\n\u003cli\u003eHypersensitivity or allergic reactions (e.g., itching, rash, urticaria) (frequency unknown).\u003c\/li\u003e\n\u003cli\u003eHeadache (less frequent).\u003c\/li\u003e\n\u003cli\u003eSore throat, cough, allergic rhinitis, nasopharyngitis (less frequent).\u003c\/li\u003e\n\u003cli\u003eAbdominal pain, nausea, diarrhoea (less frequent).\u003c\/li\u003e\n\u003cli\u003eJoint pain, lumbago (less frequent).\u003c\/li\u003e\n\u003c\/ul\u003e\u003cp\u003eAbove reactions have been reported with use of grape seed extract, but these effects occur at rates similar to placebo. Adverse effects are more likely to occur at doses above the tolerable upper intake.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eOverdose:\u003c\/strong\u003e In overdose, side effects can be precipitated and\/or be of increased severity. Treatment of overdose should be symptomatic and supportive.\u003c\/p\u003e\u003cp\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store at or below 25 °C in a cool, dry place. Store in the original package.\u003c\/p\u003e","brand":"OXIPROVIN","offers":[{"title":"Default Title","offer_id":67740147253558,"sku":"6007650000477","price":109.04,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/9136\/3126\/files\/6007650000477-onelife.jpg?v=1792123659","url":"https:\/\/onelife.co.za\/products\/oxiprovin-grape-seed-extract-140mg-30-capsules","provider":"One Life Health Store","version":"1.0","type":"link"}